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KMID : 1037620200070020145
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Pediatric Emergency Medicine Journal
2020 Volume.7 No. 2 p.145 ~ p.150
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Macrolide-refractory Mycoplasma pneumoniae pneumonia and hemophagocytic lymphohistiocytosis: case report and literature review
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Ma Sung-Yun
Kim Dan-Bi
Lee Ju-Young
Cho Kyoung-Soon
Suh Jin-Soon
Lee Soo-Young
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Abstract
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Mycoplasma pneumoniae causes various extra-pulmonary complications. As a rare but fatal hematological complication, hemophagocytic lymphohistiocytosis (HLH) can be observed in children with M. pneumoniae infection. We report a case of a 6-year-old girl with HLH who was initially presumed to have macrolide-refractory M. pneumoniae pneumonia. Despite the combination treatment of antimicrobial and anti-inflammatory agents, she showed persistent fever, hepatosplenomegaly, and thrombocytopenia. Secondary HLH associated with M. pneumoniae should be considered if unexplained clinical deterioration is noted in children with macrolide-refractory M. pneumoniae pneumonia.
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KEYWORD
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Child, Lymphohistiocytosis, Hemophagocytic, Macrolides, Mycoplasma pneumoniae, Treatment Failure
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